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vitalfork.com > Blog > Health & Wellness > Man’s brain tumor halved in therapy trial
Man’s brain tumor halved in therapy trial
Health & Wellness

Man’s brain tumor halved in therapy trial

VitalFork
Last updated: October 29, 2024 8:56 am
VitalFork
Published October 29, 2024
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Man’s brain tumor halved in therapy trialā€˜Really quite remarkable’Actor welcomes new brain tumor findingsā€˜There is no miracle cure for our brave Ronnie’Six-year-old boy is Britain’s first person in brain tumor drug trial

Man’s brain tumor halved in therapy trial

University College London Hospitals NHS Foundation Trust Paul Reid standing outside to the left of his wife Pauline. There is a lot of greenery of plants, trees and grass behind this couple. Paul and Pauline are standing close to each other and both are smiling and facing the camera. Paul wears a dark gray jacket with a red shirt and has short white hair. Pauline is wearing a cream denim jacket and a white blouse underneath. She has short white hair with a side fringe on her forehead and wears square-framed glasses. University College London Hospitals NHS Foundation Trust
Paul Reed was the first patient recruited into a new therapy trial to treat brain tumors

A man’s brain tumor has halved in just a few weeks thanks to a new radioactive therapy.

Paul Reed, 62, from Luton, was the first patient to take part in the trial aimed at treating glioblastoma, a type of cancer which kills most patients within 18 months.

The therapy, from University College London Hospitals NHS Foundation Trust (UCLH), involved injecting low levels of radioactivity directly into the tumor to kill the cancer cells.

The doctor who designed the trial said the results were ā€œremarkable for someone whose tumor is so aggressiveā€.

Surgeons removed as much of the tumor as possible before implanting a small medical device, called an Omaya reservoir, beneath the skull.

The drug ATT001, given weekly for four to six weeks, is effective at short distances, causing lethal damage to cancer cells while causing no harm to healthy tissue.

University College London Hospitals NHS Foundation Trust Side profile of Paul looking to the right. We can clearly see his scar from the brain tumor surgery and it is a thin dark purple line in an almost crescent shape. It starts just above her right eyebrow, goes to her hair, curves downwards and reaches her ear. This mark stops right in the middle of Paul's ear. Her background is blurry but looks like a medical setting with plain white walls and a computer. University College London Hospitals NHS Foundation Trust
One doctor said Mr Reed’s results were remarkable, given how aggressive his tumor was.

Mr Reed first noticed severe headaches last December and, two weeks later, his face drooped to one side.

He underwent surgery to remove as much of the tumor as possible soon after diagnosis, followed by radiotherapy and chemotherapy.

In July, doctors found the tumor was growing again and he was offered a place in the new CITADEL-123 trial at UCLH.

He said, ā€œI was fully expecting the tumor to come back due to its aggressive nature. I knew the outcome would not be good and I was happy to explore something else.ā€

ā€œI’m not afraid of any of this. We’ve all been dealt a card and you don’t know which card you’re going to get.

ā€œIt would be wonderful if this treatment helps me and if it doesn’t, it doesn’t…it may benefit someone else down the road.ā€

ā€˜Really quite remarkable’

The trial was designed by Dr Paul Mulholland, UCLH consultant medical oncologist and principal investigator.

He said: ā€œBecause it targets tumor cells directly, it is very powerful at killing them.

ā€œWe’ve just seen the results of his (Paul’s) scans and the last scan of his treatment showed a reduction in the tumor, which is really quite remarkable for someone whose tumor is so aggressive.ā€

Since this was the first human study, Dr. Mulholland said, they were cautious in their approach, but expected to increase the radiation dose and number of patients later.

More stories like this

Actor welcomes new brain tumor findings

ā€˜There is no miracle cure for our brave Ronnie’

Six-year-old boy is Britain’s first person in brain tumor drug trial

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