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Father’s high cholesterol linked to increased heart risk in daughters: Study
A new study from the University of California Riverside, led by Changcheng Zhou, suggests that a father’s high-cholesterol diet may have a negative impact on his daughter’s heart health. The study found that female infants of rats fed a high-cholesterol diet had increased arterial plaque, indicating a gender-specific risk associated with atherosclerosis. read on.
Father’s high cholesterol linked to increased heart risk in daughters: Study (Image credit: iStock)
We all know that a father’s behavior can influence a daughter’s mindset toward life, but a new study from the University of California, Riverside, shows that a father’s diet can have a significant impact on his daughter’s health. The study, led by Changcheng Zhou, found that men who consume high cholesterol diet can affect cardiovascular health of their daughters, even if they have maintained a healthy routine throughout their lives.
Cardiovascular diseases are one of the leading causes of death worldwide. Everything from daily routine to what we eat contributes to heart health. This study shows a rare connection that shows how a father’s diet can impact his daughter’s heart health. The study focused on atherosclerosis – a chronic inflammation that is one of the primary causes heart diseaseAtherosclerosis occurs when plaque, consisting of cholesterolFat and other substances accumulate in the walls of the arteries, restricting blood circulation to vital organs of the body.
Study participants:
The study involved mice lacking the LDL receptor. He was fed either a high-cholesterol diet or a normal diet for eight weeks before being mated with female rats on a normal diet. The infant rats were then placed on a normal diet and examined for atherosclerosis.
Result:
The results of the study showed that female baby rats from fathers who consumed a high-cholesterol diet developed thicker arterial plaque than other baby rats from fathers who consumed a normal diet. It was further examined whether the study results were gender-specific. Male infants of fathers on high-cholesterol diets did not show much difference.
The study researchers further revealed that female infant mice from fathers who consumed a high-cholesterol diet had increased expression of genes associated with inflammation and immune responses. These gene expressions are thought to be major factors in the development of atherosclerosis.
Study leader Changcheng Zhou said the study helps understand how environmental exposures, including unhealthy diet, environmental toxins and stress, can affect intergenerational inheritance.
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