In an unprecedented development, researchers at KAIST (Korea Advanced Institute of Science and Technology) unveiled a new technology that treats colon cancer without killing the cancer cells.

Instead, the technology converts cancer cells into a state similar to normal colon cells, effectively avoiding harmful side effects.

This innovative approach challenges the traditional perception of cancer treatment where many treatments come with limitations, risks of remission and side effects.

The research team, led by Professor Kwang-Hyun Cho of the Department of Biological and Brain Engineering, observed that during the process of oncogenesis (cancer formation), normal cells regress along their differentiation trajectory – a pathway that defines how cells Are mature and experts.

Based on this understanding, the team created a digital twin of the gene network responsible for cell differentiation.

Using advanced simulation analysis, researchers identified key molecular “master switches” that can trigger colon cancer cells to revert to a more normal state.

When these switches were applied to colon cancer cells, the results were remarkable.

Laboratory experiments, including animal tests as well as molecular and cellular studies, confirmed that cancer cells can indeed be reverted to a state that resembles normal colon cells.

Instead of relying on accidental discoveries, the team demonstrated that cancer cell reversion can be achieved systematically by analyzing and using digital twins of gene networks.

The researchers said this approach not only reduces the risk of side effects but also addresses the challenge of cancer cell resistance.

Highlighting the significance of this discovery, Professor Kwang-Hyun Cho said, “The fact that cancer cells can be transformed back into normal cells is an amazing phenomenon. This study proves that such reversion can be systematic.” “Can be inspired by form.”

He further added, “This research introduces the novel concept of reversible cancer therapy by reverting cancer cells to normal cells. It also lays the foundation for identifying precise targets for cancer reversion through systematic analysis of normal cell differentiation trajectories.” Keeps.”

The findings of this study hold promise for developing novel cancer treatments that could potentially be applied to other types of cancer as well.

As research continues, this breakthrough could revolutionize the way we tackle one of the world’s deadliest diseases.