It is a common belief that bone marrow transplant can successfully treat cancer such as leukemia and lymphoma – but many people do not know that they are also used surprisingly to treat various other conditions, some of which include genetic and autoimmune diseases, which are in addition to rare metabolic disorders.

According to experts, technology can also be used in cases of severe applastic anemia or bone marrow failure.

Bone marrow transplant, or BMT, also known as hematopoietic stem cell transplantation, is becoming a possible life-saving therapy for many different non-cancer conditions, many of which often do not recognize in India and worldwide.

“The central role that makes HSCT beyond cancer is the central role hematopoietic stem and ancestor cells play in blood formation, immune function, and cellular metabolism. In inherited immune deficiencies, a healthy immune system can restore resistance to a healthy immune system,” Dr. Rasmi Palasari, Consultant, Romai Now.

Dr. According to Palaseri, in storage and metabolic disorders, where toxins accumulate in the cells due to the deficiencies of the enzymes, donor-rituals provide systematically missing enzymes. Even in some mitochondrial and genetic disorders, transplanting of healthy stem cells can reduce the progression of the disease by introducing normal metabolism or structural cell components. He said, “This broader therapeutic capacity explains why HSCT is being used to treat the increasing number of non-fatal diseases worldwide,” he said.

What are the conditions of BMT treatment?

Some of other amazing diseases other than cancer have been treated using bone marrow implants:

Thalassemia

Thalassemia Major, or β-thalassemia, is an autosomal resistant disorder, which is characterized by the synthesis of the absent or severe decrease of the β-globin chains of hemoglobin, which resulted in severe anemia that requires life-threatening anemia. It is one of the most common signs for BMT in Indian children. Statistics from Indian implants centers suggest that about 35 percent of pediatrics have been done for Thalassemia, “Dr. Palaseri said.

The rising success rate of haploidentical HSCT has expanded access to patients with a lack of matching donors, improving the results in India. However, despite this progression, there is a sufficient difference between the number of demonstrated processes and an estimated 100,000 patients for transplantation in India. It underlines an urgent requirement for an important growth capacity and extended transplant access.

Non -anemia

Applastic anemia is a condition where the bone marrow does not produce enough blood cells and is a sign of another major non-cancer for BMT in India. Scientific studies suggest that inherited causes of aplastic anemia, such as fankoni anemia and other inherited bone marrow failure syndromes, may become more popular in the Asian population including India than in Western countries.

Doctors say that initial diagnosis of these heritage forms is necessary because they often require special management and have different genetic counseling implications. Recent data from various transplant centers in India suggests that survival results for applastic anemia patients in India are now comparable to global standards, reflecting advances in diagnosis, accessory care, and transplantation expertise.

sickle cell disease

Sickle cell disease is prevalent in parts of central and western India, where pain in condition causes crisis, infection and progressive organ damage. BMT is currently the only therapeutic treatment for this inherited disorder. Fast, Indian hospitals are offering BMT to children and young adults, allowing many of them to return to a normal and pain -free life.

In addition to BMT, gene therapy for sickle cell disease has recently shown promising results, in the international level phase 3 clinical trials. Although gene therapy is not yet widely available in India, clinical tests that discover its safety and effectiveness are underway. This emerging treatment may potentially provide less aggressive therapeutic alternative to the future.

Primary immunological disorder

Children born with severe primary immunodeficiency disorders such as viscot-aldech syndrome or severe joint immunodeficiency (SCID) face life-threatening infections. BMT can restore effective immune function. Many Indian centers have documented BMT for these rare disorders, resulting in improvement in quality of life and existence.

Autoimmune disease

Recent evidences of India and centers around the world indicate that BMT may resume the immune system in treatment-resistant autoimmune diseases such as many sclerosis, lupus and systemic sclerosis. In these cases, autologous hematopoietic stem cell transplant (auto-H.s.CT), which uses the patient’s stem cells, is usually performed.

This process involves harvesting the patient’s stem cells, followed by high doses to eliminate immune cells malfunctioned by chemotherapy or immunospaceous treatment. Sliced ​​stem cells are then resumed to “reset” the immune system, promoting the development of a new, healthy immune profile that no longer attacks the body tissues. While still considered experimental in some scenarios, early results are promising.