A new study finds that diabetes and obesity may be a cause of relapse. liver cancer Which is one of the most common forms of cancer worldwide. The study was led by researchers at Osaka Metropolitan University and published in the journal Liver Cancer. The study focused on hepatocellular carcinoma (HCC).

This is a type of liver disease that is associated with hepatitis infections and is known to have a high recurrence rate after cancer removal. It is also the third leading cause of cancer-related deaths globally. Obesity and diabetes which are closely linked to the development of metabolic syndrome.

Obesity and diabetes are major contributors to metabolic syndrome. These are a group of conditions that increase the risk of heart disease, stroke, and other health problems. Obesity, especially excess fat around the abdomen, causes insulin resistance, in which cells become less responsive to insulin. This resistance causes the body to produce more insulin, leading to type 2 diabetes. High blood sugar levels from diabetes can damage blood vessels and affect cholesterol levels, increasing the risk of cardiovascular problems. Obesity also contributes to high blood pressure and abnormal cholesterol levels, both of which are symptoms of metabolic syndrome. Excess adipose tissue, especially visceral fat, triggers inflammation and hormonal changes that worsen insulin resistance and other metabolic disturbances. Together, these conditions create a cycle that increases the risk of developing metabolic syndrome.

Metabolic syndrome is known to cause steatotic liver diseases that can lead to liver cirrhosis and ultimately HCC. However, the impact of obesity and diabetes on patient survival and cancer recurrence is unclear.

“Since obesity and diabetes have a higher risk of late recurrence in hepatocellular carcinoma, controlling obesity and diabetes is an important treatment for liver cancer,” said the research team of Dr. Hiroji Shinkawa at the university’s Graduate School of Medicine. There is a strategy.”

For the study, the team analyzed the relationship between diabetes mellitus, obesity, and postoperative outcomes in 1,644 patients with hepatocellular carcinoma who had liver resection.

The results showed that the risk of recurrence of obesity increased by approximately 1.5 times two years after the operation and in case of diabetes the risk was 1.3 times higher. Furthermore, the risk of recurrence was 3.8 times higher with obesity five years after the operation, while with diabetes, it was two times higher.

Dr Shinkawa said the findings could contribute to the early detection of cancer recurrence and the design of appropriate treatment strategies.

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