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Think twice before using OzEmpic – New Study connects it to mood disorders and brain changes
A new study increases mental health concerns about popular weight -loss drugs such as ozmpic and mounjaro. These GLP-1 agonists, while effective for hunger control, can disrupt the dopamine routes associated with mood, increase the risks of depression and suicide ideas.

Think twice before using OzEmpic – New Study connects it to mood disorders and brain change (image credit: istock)
Widely used weight loss drugs such as ozapic and silence have become increasingly popular for their ability to curb appetite and support weight loss. Relative to a class of drugs called GLP-1 receptor agonist, they were originally developed to treat type 2 diabetes, but are now often off-labeled for weight loss. These drugs a hormone, which helps to regulate blood sugar levels and appetite, mimicking the insintine.
By activating GLP-1 receptors in the brain, these drugs help users to feel more quickly and reduce crawings, making it easier to eat less. However, with his success stories, these drugs come up with a growing list of potential side effects and now, worry about their impact on mental health.
Common physical side effects include nausea, vomiting, diarrhea, constipation, abdominal pain and fatigue. More severe risks include kidney problems, gallbladder issues, pancreatitis, vision loss and even in rare cases thyroid tumors.
Now, a new study published in current neuroformacology has played alarm on possible mental health risks associated with GLP -1 agonist. Research suggests how these drugs can interact with the genes involved in mood regulation and dopamine signaling, including DRD3, BDNF, and Creb1-Genes that are associated with depression, anxiety and suicidal thoughts.
“Chronic use can disrupt dopamine signaling and increase the risk of depression and suicide ideas,” researchers warned. The study found that while GLP-1 agonist can be helpful for individuals with hyperdopaminergic conditions (too much dopamine activity), they can be harmful to people with low dopamine levels, potentially increase mental health issues.
Dr. Western University of Health Sciences and Ariel University, Dr. Dr. Kenneth Blum said, “This study should not be ignored, despite the promotion around the positive clinical consequences of the GLP -1 receptor agonist,” Dr. Western University Health Sciences and Senior Author of Aerial University, Dr. Kenneth Blum said. Co-writer and addiction psychiatry specialist Dr. Mark S. “The paper provides important evidence for re-evaluation of the wider use of the GLP-1 receptor agonist. FDA and other regulatory agencies should carefully consider our findings,” Gold said.
For those wishing to manage their weight and appetite without medicine, many natural strategies can help:
Natural ways to control hunger and lose weight:
1. Eat more protein and fiber
These nutrients help you keep you complete for a long time and reduce crawings. Eggs, lentils, beans, nuts and whole grains are great options.
2. Stay hydrated
Sometimes we make a mistake of thirst for hunger. Drinking a glass of water before meals can help reduce food intake.
3. Practice adorable food
Sleeping, avoiding distractions, and tasting your food can prevent more food and help you recognize signs of true hunger.
4. Get enough sleep
Lack of sleep affects hormones of appetite such as gruelin and leptin, often increasing craving and appetite.
5. Manage stress
Chronic stress can trigger emotional food. Techniques such as meditation, deep breathing or physical activity can help.
6. regular exercise
Physical activity not only burns calories, but also improves mood and supports metabolism.
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