Delhi-based Startup Selogen Theraputics has obtained regulatory approval for patents for the world’s first indigenously developed double-specific 3-generation region receptor T (CAR-T) cells.

What are the two-specific 3 generation of cimely antigen receptor T (CAR-T) cells?

B-specific 3 generation car T therapy is a revolutionary progression in cellular immunotherapy, which is mainly used to treat blood cancer such as leukemia, lymphoma and multiple myeloma.

Unlike traditional CAR-T therapy, which targets a single antigen (marker), the two-specific approach enables therapy to attack two tumor-specific antigens, as well as. This not only enhances efficacy, but also reduces the possibility of cancer cells developing resistance.

After the United States and China, and second in cancer -related mortality, India ranks third in cancer events. According to the Globocaine report, a global cancer database maintained by the International Agency for Research on Cancer (IARC) is for 8% of all new diagnosis cancer cases in India, more than 120,000 new cases and more than 70,000 deaths annually.

Leukemia, lymphoma and multiple myeloma affect thousands of patients every year, including about 30,000 children.

The doctor and founder of Selogen Theraputics, Dr. Gaurav Khariya said, “This approval is a will for India’s growing expertise in state -of -the -art biotechnology and accurate medicine.”

He said, “Three years of tireless research and hard work are required to develop this car-T product. Our vision has always been to develop world-class remedies that are both accessible and inexpensive,” he said.

Car-t cell therapy has been largely dominated by Western countries, with the cost of treatment more than $ 400,000 per patient. The innovation of cellogen aims to reduce these costs more than 90%, making life saving treatment more affordable.

Startup has acquired $ 2 million in funding from Natco Pharma Limited, which has gained 5.38% stake in the company. Celogen is now preparing clinical trials in collaboration with Christian Medical College (CMC), Vellore, to evaluate the therapy’s safety and efficacy.

Dr. Tanveer Ahmed, lead researcher and specialist in car-T cell therapy, highlighted the importance of innovation: “Our two-specific 3-generation CAR-T platform is the result of rigorous research and development years.

Dr. Gaurav Khariya spoke about the regulatory journey to bring therapy into clinical trials.

“This is a rigorous process. In India, we need two major regulatory agencies under the Department of Biotechnology (DBT)- RCGM (Review Committee on Genetic Herfer) and India’s Drug Controller General (DCGI) require approval under the Central Drug Standard Control Organization (CDSCO) from the Central Drug Controller General (DCGI).

Beyond blood cancer, selection envis members expand CAR-T cell therapy for solid tumors and immune-related diseases.

“Car-t therapy has great potential in treating solid tumors such as breast cancer, lung cancer and glioblastoma. Researchers are searching for the application of car-T in autoimmune diseases and chronic viral infections. This can result in successes in conditions like multiple sclerosis, lupus and even HIV,” Dr. Khari said.

One of the most important challenges in car-t therapy is its high cost. Western car-T treatment costs between $ 400,000-500,000 per patient.

“Our goal in cellogen was to reduce this cost to more than 90%. By design and producing car-T cells in India, we eliminate dependence on Western Biotech firms. In addition, we are actively engaged to create cost-deletion models with government bodies, research institutes and healthcare providers.”