This has been said in a new study weight loss Medications may cause deterioration in skeletal muscle health. In a recent commentary published in The Lancet journal, researchers from the US and Canada highlighted the critical importance of skeletal muscle in the context of medically induced weight loss, especially with its widespread use. GLP-1 receptor agonist,

GLP-1 receptors are present in popular weight loss and diabetes medications such as Ozempic, Vegovy, Monjaro, and Zepbound. GLP-1 receptors are proteins found on cell surfaces and they play an important role in regulating blood sugar levels and metabolism. These receptors stimulate insulin secretion from the pancreas while inhibiting the release of glucagon which is a hormone that increases blood sugar levels. It helps reduce blood sugar after eating.

GLP-1 receptors also influence appetite control, improving feelings of fullness and potentially helping with weight management. Medications that mimic GLP-1, known as GLP-1 receptor agonists, have been developed to help manage type 2 diabetes and obesity by improving these natural effects, thus lowering blood sugar. Helps in control and helps in weight loss.

Researchers from Pennington Biomedical Research Center in the US, Alberta and McMaster Universities in Canada argued that although the drugs have shown immense potential in treating obesity, a precursor to many diseases such as diabetes, high blood pressure and cancer, they are largely This can also be the reason. Muscle loss as part of the weight loss process.

They noted that muscle loss, measured by reduction in fat-free mass, could account for 25 to 39 percent of the total weight lost over the course of 36 to 72 weeks. The role of skeletal muscle is not only to maintain physical strength and function, but it is also important for metabolic health and regulation of the body’s immune system.

The team found that GLP-1 receptor agonists caused significantly greater declines in muscle mass than non-pharmacological calorie restriction diets or normal aging. “This may have unintended negative health consequences,” the researchers said.

People with weak muscle mass have decreased immunity, and increased risk of infection, poor glucose regulation, and other health risks. Additionally, the researchers noted that muscle loss caused by weight loss may also worsen sarcopenic obesity – which is prevalent in obese individuals, and contributes to heart disease and higher mortality rates.

Dr. Steven Heymsfield, professor of metabolism and body composition at Pennington, called on those attending weight loss drugs “Being aware of side effects”. People “are eating less and not getting the appropriate amounts of dietary vitamins and minerals” while taking the medications, he said. Researchers suggest that along with medicines, one should also consume adequate amount of protein and maximum amount of exercise.

Get the latest news live on Times Now with breaking news and top headlines from around the world.